Discovery of potential species-specific green insecticides targeting lepidopteran ryanodine receptor.

Ryanodine receptors (RyRs) are homo-tetrameric intracellular calcium (Ca2+) release channels responsible for excitation-contraction coupling of muscle cells. Diamide insecticides specifically act on RyRs of Lepidoptera and Coleoptera pests, and are safe for non-targeted organisms, generating big worldwide sales.

Despite their popularity, several devastating agricultural pests have been reported to be resistant to them due to mutations in a small transmembrane region of their RyRs, hinting a binding pocket nearby.

rHu Activin A
AK8534-0002	Akron Biotech	2µg	Ask for price

rHu Activin A
AK8534-0010	Akron Biotech	10µg	Ask for price

rHu Activin A
AK8534-0100	Akron Biotech	100µg	Ask for price

rHu Activin A
AK8534-1000	Akron Biotech	1mg	Ask for price

Activin A protein
30R-AA005	Fitzgerald	10 ug	EUR 273
Description: Purified recombinant Human Activin A protein

Activin A protein
30R-AA036	Fitzgerald	10 ug	EUR 273
Description: Purified recombinant Human Activin A protein

Activin-A Protein
20-abx262096	Abbexa	EUR 328.00 EUR 3418.00 EUR 230.00	10 ug 1 mg 2 µg

Activin-A Protein
20-abx262946	Abbexa	EUR 328.00 EUR 6397.00 EUR 230.00	10 ug 1 mg 2 µg

Activin-A Protein
20-abx262947	Abbexa	EUR 328.00 EUR 6397.00 EUR 230.00	10 ug 1 mg 2 µg

Activin-A Antibody
20-abx137208	Abbexa	EUR 704.00 EUR 328.00 EUR 230.00	100 ug 20 ug 5 ug

Activin A, CF
PR15010CF	Neuromics	50 ug	EUR 1042

Activin A ELISA Kit| Sheep Activin A ELISA Kit
EF019524	Lifescience Market	96 Tests	EUR 689

Activin A, human recombinant
4724-10	Biovision		EUR 343

Activin A, human recombinant
4724-100	Biovision		EUR 1289

Activin A, human recombinant
4724-1000	Biovision		EUR 8782

Activin A, mouse recombinant
4725-10	Biovision		EUR 343

Activin A, mouse recombinant
4725-100	Biovision		EUR 1289

Activin A, mouse recombinant
4725-1000	Biovision		EUR 8782

Activin A, rat recombinant
4726-10	Biovision		EUR 343

Activin A, rat recombinant
4726-100	Biovision		EUR 1289

Activin A, rat recombinant
4726-1000	Biovision		EUR 8782

Recombinant Activin A (ACVA)
4-RPA001Hu01	Cloud-Clone	EUR 494.24 EUR 235.00 EUR 1578.40 EUR 592.80 EUR 1085.60 EUR 394.00 EUR 3796.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Activin A expressed in: E.coli

Recombinant Human Activin-A
7-00001	Cusabio	2µg	Ask for price

Active Activin A (ACVA)
4-APA001Hu01	Cloud-Clone	EUR 809.63 EUR 320.00 EUR 2761.12 EUR 987.04 EUR 1874.08 EUR 605.00 EUR 6752.80	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Activin A expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Activin A (ACVA) Antibody
20-abx129133	Abbexa	EUR 314.00 EUR 133.00 EUR 815.00 EUR 425.00 EUR 272.00	100 ug 10 ug 1 mg 200 ug 50 ug

Activin-A Active Protein
20-abx260392	Abbexa	EUR 1970.00 EUR 230.00 EUR 328.00	100 ug 1 µg 5 ug

Activin-A, Plant Protein
20-abx262335	Abbexa	EUR 328.00 EUR 6341.00 EUR 230.00	10 ug 1 mg 2 µg

Activin-A, Active Protein
20-abx262945	Abbexa	EUR 328.00 EUR 6397.00 EUR 230.00	10 ug 1 mg 2 µg

Recombinant Human Activin-A
7-00002	CHI Scientific	10µg	Ask for price

Recombinant Human Activin-A
7-00003	CHI Scientific	1mg	Ask for price

Activin A GMP, CF
PR15122CF	Neuromics	50 ug	EUR 1654

Bovine Activin A, ACV- A ELISA Kit
ELA-67001b	Lifescience Market	96 Tests	EUR 657

Canine Activin A, ACV-A ELISA Kit
ELA-67002d	Lifescience Market	96 Tests	EUR 657

Human Activin A, ACV- A ELISA Kit
ELA-67010h	Lifescience Market	96 Tests	EUR 657

Mouse Activin A, ACV- A ELISA Kit
ELA-67033m	Lifescience Market	96 Tests	EUR 657

Porcine Activin A, ACV- A ELISA Kit
ELA-67040p	Lifescience Market	96 Tests	EUR 657

Rat Activin A, ACV- A ELISA Kit
ELA-67044r	Lifescience Market	96 Tests	EUR 657

Human Activin A,ACV-A ELISA kit
E01A1228-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Human Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Activin A,ACV-A ELISA kit
E01A1228-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Human Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Activin A,ACV-A ELISA kit
E01A1228-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Human Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin A,ACV-A ELISA kit
E02A1228-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Rat Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin A,ACV-A ELISA kit
E02A1228-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Rat Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin A,ACV-A ELISA kit
E02A1228-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Rat Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin A,ACV-A ELISA kit
E03A1228-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Mouse Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin A,ACV-A ELISA kit
E03A1228-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Mouse Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin A,ACV-A ELISA kit
E03A1228-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Mouse Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin A,ACV-A ELISA kit
E04A1228-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Rabbit Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin A,ACV-A ELISA kit
E04A1228-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Rabbit Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin A,ACV-A ELISA kit
E04A1228-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Rabbit Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Activin A, ACV-A ELISA Kit
CSB-E04486h-24T	Cusabio	1 plate of 24 wells	EUR 165
Description: Quantitative sandwich ELISA kit for measuring Human Activin A, ACV-A in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Activin A, ACV-A ELISA Kit
1-CSB-E04486h	Cusabio	EUR 500.00 EUR 3402.00 EUR 1820.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Human Activin A, ACV-A in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Activin A, ACV-A ELISA Kit
CSB-E04502m-24T	Cusabio	1 plate of 24 wells	EUR 165
Description: Quantitative sandwich ELISA kit for measuring Mouse Activin A, ACV-A in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Activin A, ACV-A ELISA Kit
1-CSB-E04502m	Cusabio	EUR 592.00 EUR 4155.00 EUR 2212.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Mouse Activin A, ACV-A in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Activin A, ACV-A ELISA Kit
CSB-E04503r-24T	Cusabio	1 plate of 24 wells	EUR 165
Description: Quantitative sandwich ELISA kit for measuring Rat Activin A, ACV-A in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Activin A, ACV-A ELISA Kit
1-CSB-E04503r	Cusabio	EUR 592.00 EUR 4155.00 EUR 2212.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Rat Activin A, ACV-A in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Monkey Activin A,ACV-A ELISA kit
E09A1228-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Monkey Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin A,ACV-A ELISA kit
E09A1228-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Monkey Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin A,ACV-A ELISA kit
E09A1228-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Monkey Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin A,ACV-A ELISA kit
E06A1228-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Goat Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin A,ACV-A ELISA kit
E06A1228-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Goat Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin A,ACV-A ELISA kit
E06A1228-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Goat Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin A,ACV-A ELISA kit
E07A1228-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Porcine Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin A,ACV-A ELISA kit
E07A1228-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Porcine Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin A,ACV-A ELISA kit
E07A1228-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Porcine Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin A,ACV-A ELISA kit
E08A1228-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Canine Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin A,ACV-A ELISA kit
E08A1228-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Canine Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin A,ACV-A ELISA kit
E08A1228-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Canine Activin A,ACV-A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Activin A,ACV-A ELISA Kit
201-12-0115	SunredBio	96 tests	EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Mouse Activin A (ACV-A) CLIA Kit
abx196700-96tests	Abbexa	96 tests	EUR 825

Rat Activin A (ACV-A) CLIA Kit
abx196701-96tests	Abbexa	96 tests	EUR 825

Rat Activin A(ACV-A)ELISA Kit
GA-E0310RT-48T	GenAsia Biotech	48T	EUR 317

Rat Activin A(ACV-A)ELISA Kit
GA-E0310RT-96T	GenAsia Biotech	96T	EUR 496

Human Activin A(ACV-A)ELISA Kit
GA-E0034HM-48T	GenAsia Biotech	48T	EUR 289

Human Activin A(ACV-A)ELISA Kit
GA-E0034HM-96T	GenAsia Biotech	96T	EUR 466

Inhibin beta A chain/Activin A/INHBA
E21-687	EnoGene	10ug	EUR 343

Rat ACV-A(Activin A) ELISA Kit
ER0004	FN Test	96T	EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 37.5pg/ml

Mouse ACV-A(Activin A) ELISA Kit
EM0013	FN Test	96T	EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 37.5pg/ml

Rat Activin A(ACV-A)ELISA Kit
QY-E11342	Qayee Biotechnology	96T	EUR 361

Mouse Activin A(ACV-A)ELISA Kit
QY-E20044	Qayee Biotechnology	96T	EUR 361

Human Activin A(ACV-A)ELISA Kit
QY-E03081	Qayee Biotechnology	96T	EUR 361

Porcine activin A (ACV-A) ELISA Kit
QY-E40054	Qayee Biotechnology	96T	EUR 400

Canine Activin A,ACV-A ELISA Kit
QY-E70056	Qayee Biotechnology	96T	EUR 426

Activin A ELISA KIT|Human
EF000021	Lifescience Market	96 Tests	EUR 689

Rat Activin A ELISA Kit
CN-01617R1	ChemNorm	96T	EUR 442

Rat Activin A ELISA Kit
CN-01617R2	ChemNorm	48T	EUR 293

Mouse Activin A ELISA Kit
CN-02488M1	ChemNorm	96T	EUR 461

Mouse Activin A ELISA Kit
CN-02488M2	ChemNorm	48T	EUR 310

Human Activin A ELISA Kit
CN-03163H1	ChemNorm	96T	EUR 441

Human Activin A ELISA Kit
CN-03163H2	ChemNorm	48T	EUR 291

Human Activin A ELISA kit
E01A0643-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Activin A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Activin A ELISA kit
E01A0643-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Human Activin A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Activin A ELISA kit
E01A0643-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Human Activin A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin A ELISA kit
E02A0643-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Activin A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin A ELISA kit
E02A0643-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Activin A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin A ELISA kit
E02A0643-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Activin A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin A ELISA kit
E04A0643-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Activin A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

A potential solution to overcome resistance is to develop new insecticides targeting different binding sites in pest RyRs. Based on a high-resolution crystal structure of diamondback moth (DBM) RyR N-terminal domain (NTD) determined by our group, we carried out extensive structure-based insecticide screening targeting the inter-subunit interface.